Article

Inferring genetic variant networks by leveraging pleiotropy shows trait relationships drive massive pleiotropy in GWAS

2024-06-03

Abstract excerpt

<h4>Summary</h4> Genetic variants have been associated with multiple traits through genome-wide association studies (GWASs), but pinpointing causal variants and their mechanisms remains challenging. Molecular phenotypes, such as eQTLs, are routinely used to interpret GWAS results. However, much concern has recently been raised about their weak overlap. Taking the opposite approach with PRISM (Pleiotropic Relation...

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Literature Corpus work: 9cd7034f-1cab-57f4-9a90-294e73e44af4
DOI: 10.1101/2024.06.01.24308193

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