Article

Hematopoietic stem cell aging promotes TET2 clonal hematopoiesis

2026-02-09

Abstract excerpt

<title>Abstract</title> <p>Aging is strongly associated with the incidence of clonal hematopoiesis (CH) and myeloid malignancies. However, the role of aging in the clonal selection for CH mutations is not well understood. In a mouse model of CH, we observe that transplanted Tet2 KO hematopoietic stem cells (HSC) from old donor mice expand at a faster rate than young irrespective of the age of the recipient mice;...

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Literature Corpus work: d876ef33-29df-58f4-97e1-12a0d05951eb
DOI: 10.21203/rs.3.rs-8704827/v1

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