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Aging and leukemic evolution of hematopoietic stem cells under various stress conditions

5 Nov 2020

Abstract excerpt

Hematopoietic stem cells (HSCs) have self-renewal capacity and differentiation potential into all lineages of blood cells throughout the lifetime of an organism. The function of HSCs gradually changes during aging. To date, various stress factors influencing HSC aging have been identified. The increased production of reactive oxygen species and DNA damage responses are causatively attributed to HSC aging. The...

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PMID: 33292805
DOI: 10.1186/s41232-020-00138-3

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