Article

Transplantation and old stem cell age independently increase the risk of clonal hematopoiesis in long-term survivors of pediatric HCT

2024-09-30

Abstract excerpt

In pediatric hematopoietic cell transplantation (HCT) recipients, transplanted donor cells may need to function far beyond normal human lifespan. Here, we investigated the risk of clonal hematopoiesis (CH) in 144 pediatric long-term HCT survivors, compared to 115 healthy controls. CH was detected in 16% of HCT survivors, at variant allele frequencies (VAFs) of 0.01-0.31. Mutations were predominantly in DNMT3A (80%...

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Literature Corpus work: 59fa3bad-e574-56da-9285-9c3f4293eefb
DOI: 10.1101/2024.09.28.24314531

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