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Article

Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling.

Blood - 23 Feb 2023

Caiado Francisco, Kovtonyuk Larisa V, Gonullu Nagihan G, Fullin Jonas, Boettcher Steffen, Manz Markus G

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP), also referred to as aging-related clonal hematopoiesis, is defined as an asymptomatic clonal expansion of mutant mature hematopoietic cells in ≥4% of blood leukocytes. CHIP associates with advanced age and increased risk for hematological malignancy, cardiovascular disease, and all-cause mortality. Loss-of-function somatic mutations in TET2 are frequent...

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Identifiers

PMID: 36379023
DOI: 10.1182/blood.2022016835
PMCID: PMC10651783

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