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Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil

8 Jun 2018

Abstract excerpt

The recent characterization of clonal hematopoiesis in a large segment of the aging population has raised tremendous interest and concern alike. Mutations have been documented in genes associated with hematological cancers and in non-driver candidates. These mutations are present at low frequency in the majority of individuals after middle-age, and principally affect the epigenetic modifiers DNMT3A and TET2. In...

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PMID: 29883022
DOI: 10.1002/stem.2845

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