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CHIP: is clonal hematopoiesis a surrogate for aging and other disease?

Hematology. American Society of Hematology. Education Program - 10 Dec 2021

Gondek Lukasz P

Abstract excerpt

Somatic mutations are an unavoidable consequence of aging tissues. Even though most mutations are functionally silent, some may affect genes critical to proper tissue self-renewal and differentiation, resulting in the outgrowth of affected cells, also known as clonal expansion. In hematopoietic tissue such clonal dominance is known as clonal hematopoiesis (CH). Sporadic CH is frequent in aging and affects over...

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Identifiers

PMID: 34889429
DOI: 10.1182/hematology.2021000270
PMCID: PMC8791098

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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