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Article

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.

Current opinion in neurobiology - 1 Feb 2016

Villegas-Llerena Claudio, Phillips Alexandra, Garcia-Reitboeck Pablo, Hardy John, Pocock Jennifer M

Abstract excerpt

Neuroinflammation is a pathological hallmark of Alzheimer's disease (AD), and microglia, the brain's resident phagocyte, are pivotal for the immune response observed in AD. Microglia act as sentinel and protective cells, but may become inappropriately reactive in AD to drive neuropathology. Recent Genome Wide Association Studies (GWAS) have identified more than 20 gene variants associated with an increased risk...

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Source

Identifiers

PMID: 26517285
DOI: 10.1016/j.conb.2015.10.004

Genes

ABCA7
CLU
EPHA1
SORL1
APOE
BIN1
PICALM
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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