Article

A CAR-T Cell-Based Strategy for Eliminating Pathogenic Microglia in ALS

2025-12-29

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative diseases are defined by the propagation of neuroinflammation, driven in part by disease-associated microglia (DAM) that amplify inflammatory signaling and hasten neurodegeneration. Strategies to selectively eliminate DAM to attenuate disease progression remain elusive. Using existing datasets in combination with multiplexed immunofluorescence analysis of post-mortem ALS tissues...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dcefb70f-b435-5c2c-8b31-c6a24c0dc1dc
DOI: 10.64898/2025.12.29.696307

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A CAR-T Cell-Based Strategy for Eliminating Pathogenic Microglia in ALSDOI 10.64898/2025.12.29.696307Read

Unveiling the Impact of Microglial Cells in Alzheimer's Disease Pathogenesis: Insights from Single-Cell RNA-seq Analysis and In Vivo ValidationSemantic proximity Read

ALS monocyte-derived microglia reveal cytoplasmic TDP-43 accumulation, DNA damage, and cell-specific impairment of phagocytosis associated with disease progressionSemantic proximity Read

An integrated human forebrain organoid reveals microglia-mediated CD8⁺ T cell recruitment and neuroimmune dysfunction in Alzheimer’s disease pathologySemantic proximity Read

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse ModelSemantic proximity Read

iPSC-Derived PSEN2 (N141I) Astrocytes and Microglia Exhibit a Primed Inflammatory PhenotypeSemantic proximity Read

PICALM regulates a human microglial antigen presentation program in Alzheimer’s diseaseSemantic proximity Read

Defective phagocytic function of induced microglia-like cells is correlated with rapid progression of sporadic ALSSemantic proximity Read

A multi-pronged human microglia response to Alzheimer’s disease Aβ pathologySemantic proximity Read

Microglia Heterogeneity in Alzheimer’s Disease: Insights From Single-Cell TechnologiesSemantic proximity Read

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.Semantic proximity Read

Microglia replacement effectively attenuates the disease progress of ALSP in the mouse model and human patientSemantic proximity Read

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseasesSemantic proximity Read