Article
IPSC-derived neuronal cultures expressing the Alzheimer’s disease associated rare TREM2 R47H variant enables the construction of an Aβ-induced gene regulatory network
2019-05-29
Abstract excerpt
Recently, genes associated with immune response and inflammation have been identified as genetic risk factors for late-onset Alzheimer’s disease (LOAD). One of them is the rare p.Arg47His (R47H) variant within triggering receptor expressed on myeloid cells 2 (TREM2), which has been shown to increase the risk for developing AD 2-3-fold. Here, we report the generation and characterization of a model of LOAD using ly...
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Identifiers and source
- Literature Corpus work
- bfa8b0c4-2cf9-500f-b4b9-17947aa02cbf
- DOI
- 10.1101/652446