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Large-scale HLA immunopeptidome and interactome profiling in microglia

2025-04-26

Abstract excerpt

Microglia are immune cells of the brain and act as major antigen presenting cells. Antigen presentation involves the human leukocyte antigen (HLA) complex, which is implicated in genetic risk of multiple neurodegenerative diseases. How HLA affects the function of microglia in the context of neurodegenerative disease remains unclear. Here, we investigated the HLA epitopes and their protein interactome in human indu...

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Literature Corpus work
1943bad3-aa3b-57fd-b23f-79ff2af35138
DOI
10.1101/2025.04.23.650327
Open publication

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Large-scale HLA immunopeptidome and interactome profiling in microgliaDOI 10.1101/2025.04.23.650327
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