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Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice

2023-08-04

Abstract excerpt

<title>Abstract</title> <p>Microglia play diverse pathophysiological roles in Alzheimer’s disease (AD), with genetic susceptibility factors skewing microglial cell function to influence AD risk. CD33 is an immunomodulatory receptor associated with AD susceptibility through a single nucleotide polymorphism that modulates mRNA splicing, skewing protein expression from a long protein isoform (CD33M) to a short isofo...

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Literature Corpus work
a09d4890-3beb-57f8-8e45-197bc90bfe18
DOI
10.21203/rs.3.rs-3147035/v1
Open publication

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Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceDOI 10.21203/rs.3.rs-3147035/v1
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