Article
Functional CENP-B boxes are selectively conserved at centromeric regions
2026-05-26
Abstract excerpt
Human centromeres are built over large stretches of repetitive, divergent α-satellite DNA. Within these sequences lies a conserved, defined 17-bp sequence named the CENP-B box that is bound by the DNA-binding protein CENP-B. Recent studies have proposed that CENP-B box motifs along chromosome arms exist and may represent conserved, ectopic binding sites with functional relevance. Here, we evaluate the genomic dist...
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Identifiers and source
- Literature Corpus work
- d82f735d-0de9-5d70-8e04-e178f554d8cb
- DOI
- 10.64898/2026.05.25.727640