Article

Drosophila larval brain neoplasms present tumour-type dependent genome instability

2017-09-22

Abstract excerpt

<h4>ABSTRACT</h4> Single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) are found at different rates in human cancer. To determine if these genetic lesions appear in Drosophila tumours we have sequenced the genomes of 17 malignant neoplasms caused by mutations in l(3)mbt, brat, aurA , or lgl . We have found CNVs and SNPs in all the tumours. Tumour-linked CNVs range between 11 and 80 per sample,...

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Literature Corpus work: d804e86d-779b-5aeb-923a-e2078bfdf114
DOI: 10.1101/192492

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