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Article

Illuminati: a form of gene expression plasticity in Drosophila neural stem cells.

Development (Cambridge, England) - 15 Nov 2022

Goupil Alix, Heinen Jan Peter, Salame Riham, Rossi Fabrizio, Reina Jose, Pennetier Carole, Simon Anthony, Skorski Patricia, Louzao Anxela, Bardin Allison J, Basto Renata, Gonzalez Cayetano

Abstract excerpt

While testing for genome instability in Drosophila as reported by unscheduled upregulation of UAS-GFP in cells that co-express GAL80 and GAL4, we noticed that, as expected, background levels were low in most developing tissues. However, GFP-positive clones were frequent in the larval brain. Most of these clones originated from central brain neural stem cells. Using imaging-based approaches and genome sequencing,...

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PMID: 36399062
DOI: 10.1242/dev.200808
PMCID: PMC9845751

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