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The Drosophila cancer-germline, head-to-head gene pair <i>TrxT</i> and <i>dhd</i> is dispensable for normal brain development but plays a major role in <i>l(3)malignant brain tumour</i> growth

2023-11-23

Abstract excerpt

<h4>ABSTRACT</h4> Drosophila thioredoxins Deadhead (Dhd) and Thioredoxin-T (TrxT) are encoded by a head-to-head gene pair in the X chromosome. Akin to human cancer-germline (CG) genes, dhd and TrxT expression is normally sex and germline specific, but becomes upregulated in brain tumours of either sex caused by mutation in l(3)malignant brain tumour ( l(3)mbt ). Using CRISPR/Cas9-mediated knock-out alleles a...

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Literature Corpus work
b8597196-3171-5616-a998-abd7643369db
DOI
10.1101/2023.11.23.568462
Open publication

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The Drosophila cancer-germline, head-to-head gene pair <i>TrxT</i> and <i>dhd</i> is dispensable for normal brain development but plays a major role in <i>l(3)malignant brain tumour</i> growthDOI 10.1101/2023.11.23.568462
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