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Article

Identification of 2R-ohnologue gene families displaying the same mutation-load skew in multiple cancers.

Open biology - 7 May 2014

Tinti Michele, Dissanayake Kumara, Synowsky Silvia, Albergante Luca, MacKintosh Carol

Abstract excerpt

The complexity of signalling pathways was boosted at the origin of the vertebrates, when two rounds of whole genome duplication (2R-WGD) occurred. Those genes and proteins that have survived from the 2R-WGD-termed 2R-ohnologues-belong to families of two to four members, and are enriched in signalling components relevant to cancer. Here, we find that while only approximately 30% of human transcript-coding genes...

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Identifiers

PMID: 24806839
DOI: 10.1098/rsob.140029
PMCID: PMC4042849

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