Article
DNA copy number evolution in Drosophila cell lines.
Genome biology - 28 Aug 2014
Lee Hangnoh, McManus C Joel, Cho Dong-Yeon, Eaton Matthew, Renda Fioranna, Somma Maria Patrizia, Cherbas Lucy, May Gemma, Powell Sara, Zhang Dayu, Zhan Lijun, Resch Alissa, Andrews Justen, Celniker Susan E, Cherbas Peter, Przytycka Teresa M, Gatti Maurizio, Oliver Brian, Graveley Brenton, MacAlpine David
Abstract excerpt
BACKGROUND: Structural rearrangements of the genome resulting in genic imbalance due to copy number change are often deleterious at the organismal level, but are common in immortalized cell lines and tumors, where they may be an advantage to cells. In order to explore the biological consequences of copy number changes in the Drosophila genome, we resequenced the genomes of 19 tissue-culture cell lines and...
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