Article
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.
Nature communications - 31 Oct 2017
Cheng Jiqiu, Demeulemeester Jonas, Wedge David C, Vollan Hans Kristian M, Pitt Jason J, Russnes Hege G, Pandey Bina P, Nilsen Gro, Nord Silje, Bignell Graham R, White Kevin P, Børresen-Dale Anne-Lise, Campbell Peter J, Kristensen Vessela N, Stratton Michael R, Lingjærde Ole Christian, Moreau Yves, Van Loo Peter
Abstract excerpt
Homozygous deletions are rare in cancers and often target tumour suppressor genes. Here, we build a compendium of 2218 primary tumours across 12 human cancer types and systematically screen for homozygous deletions, aiming to identify rare tumour suppressors. Our analysis defines 96 genomic regions recurrently targeted by homozygous deletions. These recurrent homozygous deletions occur either over tumour...
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