Article

Distinct transcriptional programs define human IgG4 <sup>+</sup> memory B cells

2026-06-09

Abstract excerpt

Human immunoglobulin G4 (IgG4) shapes both protective and pathogenic immunity, influencing conditions ranging from allergy and autoimmunity to cancer. However, subclass-specific targeting of memory B cells remains challenging due to limited knowledge of their phenotypic and functional heterogeneity. Here, we show that IgG4 + memory B cells are overrepresented in a niche of FCER2 + BAFFR + memory B cells, can be...

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Literature Corpus work: 678d3d4f-60cc-5ff8-aa68-4eb0f91a7f02
DOI: 10.64898/2026.06.05.728165

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