Article

An inducible CRISPR-ON system for controllable gene activation in human pluripotent stem cells

2017-02-05

Abstract excerpt

Human pluripotent stem cells (hPSCs) are an important system to study early human development, model human diseases, and develop cell replacement therapies. However, genetic manipulation of hPSCs is challenging and a method to simultaneously activate multiple genomic sites in a controllable manner is sorely needed. Here, we constructed a CRISPR-ON system to efficiently upregulate endogenous genes in hPSCs. A doxyc...

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Literature Corpus work: d7c62c02-e92f-5d63-a224-0ef72311f1b5
DOI: 10.1101/106112

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