Article

Multiplex genome editing of human pluripotent stem cells using Cpf1

2022-04-13

Abstract excerpt

Targeted genome editing of human pluripotent stem cells (hPSC) is critical for basic and translational research, and can be achieved with site-specific endonucleases. Class 2 clustered regularly interspaced short palindromic repeats (CRISPR) Cpf1 represents a class of RNA programmable DNA endonucleases with features that could be complementary to the widely used Class 1 CRISPR-Cas9 system. Here we engineered a sin...

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Literature Corpus work: 8daaddc0-c19c-589d-818c-a08207f86557
DOI: 10.1101/2022.04.13.488123

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