Article

Relating evolutionary selection and mutant clonal dynamics in normal epithelia

2018-11-28

Abstract excerpt

Cancer develops from mutated cells in normal tissues. Whether somatic mutations alter normal cell dynamics is key to understanding cancer risk and guiding interventions to reduce it. An analysis of the first incomplete moment of size distributions of clones carrying cancer-associated mutations in normal human eyelid skin gives a good fit with neutral drift, arguing mutations do not affect cell fate. However, this...

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Literature Corpus work: d79c9bf1-99e9-5c12-94c5-249bf8ec9289
DOI: 10.1101/480756

Open publication

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