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Different responses to cell crowding determine the clonal fitness of <i>p53</i> and <i>Notch</i> inhibiting mutations in squamous epithelia

2020-04-01

Abstract excerpt

The growth and competition of cells in epithelial tissues plays an important role in both tissue homeostasis and the robustness of normal tissues to pre-cancer mutation. Whilst wild-type cells compete neutrally for dominance in the un-mutated tissue, naturally occurring mutations in individual cells may lend them a fitness advantage that can allow tissue colonisation. In mouse oesophageal epithelia, the growth of...

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Literature Corpus work
205f4eb0-4d73-553f-bacb-36264c67227a
DOI
10.1101/2020.03.30.015917
Open publication

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Different responses to cell crowding determine the clonal fitness of <i>p53</i> and <i>Notch</i> inhibiting mutations in squamous epitheliaDOI 10.1101/2020.03.30.015917
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