Article
Spatial constraints govern competition of mutant clones in human epidermis.
Nature communications - 24 Oct 2017
Lynch M D, Lynch C N S, Craythorne E, Liakath-Ali K, Mallipeddi R, Barker J N, Watt F M
Abstract excerpt
Deep sequencing can detect somatic DNA mutations in tissues permitting inference of clonal relationships. This has been applied to human epidermis, where sun exposure leads to the accumulation of mutations and an increased risk of skin cancer. However, previous studies have yielded conflicting conclusions about the relative importance of positive selection and neutral drift in clonal evolution. Here, we sequenced...
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