Article

Early <i>NOTCH1</i> mutation is positively selected but epistatically suppresses evolution of later esophageal squamous-cell carcinoma drivers

2023-11-05

Abstract excerpt

<h4>Background</h4> Somatic mutations commonly accumulate in histologically normal tissues and contribute to cancer development. However, many mutations that are common in normal tissue are also found in cancers from the same organ, making their role in malignant progression unclear. To address this, we asked whether such mutations increase cell proliferation and survival to different degrees at different steps o...

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Literature Corpus work: 1d41967b-328c-5d0f-b8e4-06ca82d4c784
DOI: 10.1101/2023.11.03.565535

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