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Article

Simulations reveal that different responses to cell crowding determine the expansion of p53 and Notch mutant clones in squamous epithelia.

Journal of the Royal Society, Interface - 1 Oct 2021

Kostiou Vasiliki, Hall Michael W J, Jones Philip H, Hall Benjamin A

Abstract excerpt

During ageing, normal epithelial tissues progressively accumulate clones carrying mutations that increase mutant cell fitness above that of wild-type cells. Such mutants spread widely through the tissues, yet despite this cellular homeostasis and functional integrity of the epithelia are maintained. Two of the genes most commonly mutated in human skin and oesophagus are p53 and Notch1, both of which are also...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34637643
DOI: 10.1098/rsif.2021.0607
PMCID: PMC8510697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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