Article

Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology

2023-03-04

Abstract excerpt

Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its association with a typical movement disorder. Direct effects of mutant HTT (mHTT) in the striatum may cause neuropathology, although non-cell autonomous effects have also been suggested. Important non-motor features of...

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Literature Corpus work: d79139bc-be6d-5196-b856-41bde5ff05e0
DOI: 10.1101/2023.03.04.530949

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