Article
Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.
Cell metabolism - 6 Apr 2011
Hult Sofia, Soylu Rana, Björklund Tomas, Belgardt Bengt F, Mauer Jan, Brüning Jens C, Kirik Deniz, Petersén Åsa
Abstract excerpt
In Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be limited to the basal ganglia, but recent studies have suggested a more widespread pathology involving hypothalamic dysfunction. Here we tested the hypothesis that expression of mutant huntingtin in the hypothalamus causes metabolic abnormalities. First, we showed that bacterial artificial...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.