Article

Effects of excitotoxicity in the hypothalamus in transgenic mouse models of Huntington disease

2021-04-10

Abstract excerpt

Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT). The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected. The hypothalamus has emerged as an important area of pathology with selective loss of neurons expressing the neuropeptides orexin (hypocretin), oxytocin and vasopressin in human pos...

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Literature Corpus work: 60efc96c-e6f6-55b9-b004-89701c45e15f
DOI: 10.1101/2021.04.08.439100

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