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Article

Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice.

Acta neuropathologica communications - 7 Dec 2025

Oraha Jennifer, Wagner Ronja, Bergh Sofia, Lee Nicola J, Kirik Deniz, Petersén Åsa

Abstract excerpt

The spectrum of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) and Huntington disease (HD) are fatal neurodegenerative disorders with no major disease-modifying therapies. Recent work has shown that the hallmark pathological proteins TAR DNA binding protein of 43 kDa (TDP-43) in FTD/ALS and mutant huntingtin (mHTT) in HD may be interlinked. Furthermore, these disorders share early features of...

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Identifiers

PMID: 41354852
DOI: 10.1186/s40478-025-02201-x
PMCID: PMC12706952

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Differential effects of overexpression of mutant huntingtin and TDP-43 in agouti-related protein neurons in the arcuate nucleus of the hypothalamus in mice.PMID 41354852Read ↗

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