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Article

Dysfunctional striatal dopamine signaling in Huntington's disease

15 Jul 2019

Abstract excerpt

Dopamine signaling in the striatum is critical for a variety of behaviors including movement, behavioral flexibility, response to reward and many forms of learning. Alterations to dopamine transmission contribute to pathological features of many neurological diseases, including Huntington's disease (HD). HD is an autosomal dominant genetic disorder caused by a CAG repeat expansion in the Huntingtin gene. The...

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PMID: 31304622
DOI: 10.1002/jnr.24495

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