Article

PYK2 in the dorsal striatum of Huntington’s disease R6/2 mouse model

2024-01-20

Abstract excerpt

Huntington’s disease (HD) is a devastating disease due to autosomal dominant mutation in the HTT gene. Its pathophysiology involves multiple molecular alterations including transcriptional defects. We previously showed that in HD patients and mouse model, the protein levels of the non-receptor tyrosine kinase PYK2 were decreased in the hippocampus and that viral expression of PYK2 improved the hippocampal phenoty...

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Literature Corpus work: 979c90a6-d317-5461-aca2-99717ab79d46
DOI: 10.1101/2024.01.18.576195

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