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Article

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice.

Molecular metabolism - 1 Mar 2022

Dickson Elna, Soylu-Kucharz Rana, Petersén Åsa, Björkqvist Maria

Abstract excerpt

OBJECTIVE: In Huntington's disease (HD), the disease-causing huntingtin (HTT) protein is ubiquitously expressed and causes both central and peripheral pathology. In clinical HD, a higher body mass index has been associated with slower disease progression, indicating the role of metabolic changes in disease pathogenesis. Underlying mechanisms of metabolic changes in HD remain poorly understood, but recent studies...

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Identifiers

PMID: 35007790
DOI: 10.1016/j.molmet.2022.101439
PMCID: PMC8814380

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