Article

Microarray profiling of hypothalamic gene expression changes in Huntington’s disease mouse models

2022-03-17

Abstract excerpt

Structural changes and neuropathology in the hypothalamus have been suggested to contribute to the non-motor manifestations of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. In the present study, we investigated whether transcriptional changes would be part of hypothalamic pathology induced by the disease-causing huntingtin (HTT) protein. We p...

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Literature Corpus work: 0537d0d0-2321-51f0-ab3f-26cee46311fd
DOI: 10.1101/2022.03.15.484411

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