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Article

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice

30 May 2000

Abstract excerpt

In Huntington's disease (HD), mutation of huntingtin causes selective neurodegeneration of dopaminoceptive striatal medium spiny neurons. Transgenic HD model mice that express a portion of the disease-causing form of human huntingtin develop a behavioral phenotype that suggests dysfunction of dopaminergic neurotransmission. Here we show that presymtomatic mice have severe deficiencies in dopamine signaling in the...

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PMID: 10829080
DOI: 10.1073/pnas.120166397

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