Article

Up-regulation of NGEF by ERK/AP1 signaling pathway in BRAFV600E-mutant thyroid cancer promotes cancer metastasis

2023-05-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> The BRAFV600E mutation is the most frequent genetic mutation in thyroid tumors, and is therefore a key therapeutic target. However, intrinsic feedback mechanisms impact the clinical use of BRAFV600E-specific inhibitors. Further investigations into the specific roles and molecular mechanisms underlying BRAFV600E in thyroid cancer progression are required.<bold>Met...

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Literature Corpus work: d77e0bf6-5b15-5573-97cf-371e2d335e26
DOI: 10.21203/rs.3.rs-2865959/v1

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