Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF-induced EHF Expression Affects TERT in Aggressive Papillary Thyroid Cancer.

The Journal of clinical endocrinology and metabolism - 18 Feb 2025

Xu Yiyi, Gao Jiwei, Wang Na, Zedenius Jan, Nilsson Inga-Lena, Lui Weng-Onn, Xu Dawei, Juhlin C Christofer, Larsson Catharina, Mu Ninni

Abstract excerpt

CONTEXT: BRAFV600E and TERT promoter mutations in papillary thyroid carcinoma (PTC) have a synergistic effect on prognosis. This effect is believed to arise from MAPK activation triggered by BRAFV600E, leading to the upregulation of ETS transcription factors that bind to the mutant TERT promoter. OBJECTIVES: To explore the role of ETS factors in relation to clinical features, BRAFV600E, and TERT promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pituitary Gland Disorders and Treatments
Share to Thyroid and Parathyroid Surgery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Thyroid Cancer Diagnosis and Treatment

Source

Open in PubMed Open full text

Identifiers

PMID: 39183149
DOI: 10.1210/clinem/dgae589
PMCID: PMC11834717

Genes

TERT
EHF
BRAF
ERG
ETS1
ETV6
FLI1
GABPA
SPDEF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF-induced EHF Expression Affects TERT in Aggressive Papillary Thyroid CancerPMID 39183149Read ↗

Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancerSemantic proximity Read ↗

Impact of BRAF V600E and TERT Promoter Mutations on Response to Therapy in Papillary Thyroid CancerSemantic proximity Read ↗

Prospective Analysis of TERT Promoter Mutations in Papillary Thyroid Carcinoma at a Single InstitutionSemantic proximity Read ↗

TERT expression is susceptible to BRAF and ETS-factor inhibition in BRAFV600E/TERT promoter double-mutated gliomaSemantic proximity Read ↗

TERT promoter Mutation and Its Association with Clinicopathological Features and Prognosis of Papillary Thyroid Cancer: A Meta-analysis.Semantic proximity Read ↗

The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer CellsSemantic proximity Read ↗

Gene Expression Profiles of AHNAK2, DCSTAMP, FN1, and TERT Correlate With Mutational Status and Recurrence in Papillary Thyroid Carcinoma.Semantic proximity Read ↗

Clinicopathological significance of TERT promoter mutation in papillary thyroid carcinomas: a systematic review and meta-analysis.Semantic proximity Read ↗

Clinicopathological indicators for TERT promoter mutation in papillary thyroid carcinoma.Semantic proximity Read ↗

The predictive value of coexisting BRAFV600E and TERT promoter mutations on poor outcomes and high tumour aggressiveness in papillary thyroid carcinoma: A systematic review and meta-analysis.Semantic proximity Read ↗

Preoperative Co-Mutation of BRAFV600E and TERT Promoter Predicts Tumor Aggressiveness and Recurrence-Free Survival in Papillary Thyroid Carcinoma.Semantic proximity Read ↗

TERT promoter mutations and long-term survival in patients with thyroid cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.