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Article

Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer.

Nature communications - 8 Feb 2018

Liu Rengyun, Zhang Tao, Zhu Guangwu, Xing Mingzhao

Abstract excerpt

The unique oncogene duet of coexisting BRAF V600E and TERT promoter mutations are widely found to be a robust genetic background promoting human cancer aggressiveness, but the mechanism is unclear. Here, we demonstrate that the BRAF V600E/MAP kinase pathway phosphorylates and activates FOS, which in turn acts as a transcription factor to bind and activate the GABPB promoter, increasing GABPB expression and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins B-raf

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Source

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Identifiers

PMID: 29422527
DOI: 10.1038/s41467-018-03033-1
PMCID: PMC5805723

Genes

TERT
BRAF
FOS
GABPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of mutant TERT by BRAF V600E/MAP kinase pathway through FOS/GABP in human cancer.PMID 29422527Read ↗

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