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Article

BRAF<sup>V600E</sup>Promotes Invasiveness of Thyroid Cancer Cells through Nuclear Factor κB Activation

8 Sept 2006

Abstract excerpt

The BRAFV600E mutation is closely linked to tumorigenesis and malignant phenotype of papillary thyroid cancer. Signaling pathways activated by BRAFV600E are still unclear except a common activation pathway, MAPK cascade. To investigate the possible target of BRAFV600E, we developed two different cell culture models: 1) doxycycline-inducible BRAFV600E-expressing clonal line derived from human thyroid cancer WRO...

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PMID: 16959844
DOI: 10.1210/en.2006-0400

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