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Article

BRAF(V600E) mutation influences hypoxia-inducible factor-1alpha expression levels in papillary thyroid cancer.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2010

Zerilli Monica, Zito Giovanni, Martorana Anna, Pitrone Maria, Cabibi Daniela, Cappello Francesco, Giordano Carla, Rodolico Vito

Abstract excerpt

Hypoxia-inducible factor-1alpha is found frequently overexpressed in solid tumors cells, exerting an important role in angiogenesis, glucose metabolism, cell proliferation, survival and invasion. In thyroid carcinomas, hypoxia-inducible factor-1alpha expression was found increased in differentiated, poorly differentiated, medullary and anaplastic variants. Hypoxia represents the principal stimulus responsible for...

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Share to Adenocarcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20473281
DOI: 10.1038/modpathol.2010.86

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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BRAF(V600E) mutation influences hypoxia-inducible factor-1alpha expression levels in papillary thyroid cancer.PMID 20473281Read ↗

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