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New Insights into FoxE1 Functions: Identification of Direct FoxE1 Targets in Thyroid Cells

13 May 2013

Abstract excerpt

BACKGROUND: FoxE1 is a thyroid-specific forkhead transcription factor essential for thyroid gland development, as well as for the maintenance of the thyroid differentiated state in adults. FoxE1 recognizes and binds to a short DNA sequence present in thyroglobulin (Tg) and thyroperoxidase (Tpo) promoters, but FoxE1 binding to regulatory regions other than Tg and Tpo promoters remains almost unexplored. Improving...

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PMID: 23675434
DOI: 10.1371/journal.pone.0062849

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