Article
FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma.
Endocrine-related cancer - 1 Oct 2012
Bellelli Roberto, Castellone Maria Domenica, Garcia-Rostan Ginesa, Ugolini Clara, Nucera Carmelo, Sadow Peter M, Nappi Tito Claudio, Salerno Paolo, Cantisani Maria Carmela, Basolo Fulvio, Gago Tomas Alvarez, Salvatore Giuliana, Santoro Massimo
Abstract excerpt
Anaplastic thyroid carcinoma (ATC) is a very aggressive thyroid cancer. forkhead box protein M1 (FOXM1) is a member of the forkhead box family of transcription factors involved in control of cell proliferation, chromosomal stability, angiogenesis, and invasion. Here, we show that FOXM1 is significantly increased in ATCs compared with normal thyroid, well-differentiated thyroid carcinomas (papillary and/or...
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