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Article

Overexpression of the pro-protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF/MEK signaling.

Molecular oncology - 1 Jul 2023

Poyil Pratheesh Kumar, Siraj Abdul K, Padmaja Divya, Parvathareddy Sandeep Kumar, Diaz Roxanne, Thangavel Saravanan, Begum Rafia, Haqawi Wael, Al-Mohanna Falah Hassan, Al-Sobhi Saif S, Al-Dayel Fouad, Al-Kuraya Khawla S

Abstract excerpt

Furin belongs to the pro-protein convertases (PCs) family and its aberrant expression has been documented in various types of cancers; however, its role in thyroid cancer remains unclear. We investigated the expression of furin in a large cohort of Middle Eastern papillary thyroid carcinoma (PTC) patient samples and explored its functional role and mechanism in PTC cell lines in vitro and in vivo. Furin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36799665
DOI: 10.1002/1878-0261.13396
PMCID: PMC10323895

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