Article

Poly ADP-Ribose Signaling is Dysregulated in Huntington Disease

2022-11-24

Abstract excerpt

Huntington disease (HD) is a genetic neurodegenerative disease caused by CAG expansion in the Huntingtin (HTT) gene, translating to an expanded polyglutamine tract in the huntingtin (HTT) protein. Age at disease onset correlates to CAG repeat length but varies by decades between individuals with identical repeat lengths. Genome-wide association studies link HD modification to DNA repair and mitochondrial health p...

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Literature Corpus work: 208220ec-6981-5346-8b61-8a5dbf54785b
DOI: 10.1101/2022.11.23.517669

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