Article
Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.
Molecular neurobiology - 1 Jun 2014
Ferlazzo Mélanie L, Sonzogni Laurène, Granzotto Adeline, Bodgi Larry, Lartin Océane, Devic Clément, Vogin Guillaume, Pereira Sandrine, Foray Nicolas
Abstract excerpt
Huntington's disease (HD) is a neurodegenerative syndrome caused by mutations of the IT15 gene encoding for the huntingtin protein. Some research groups have previously shown that HD is associated with cellular radiosensitivity in quiescent cells. However, there is still no mechanistic model explaining such specific clinical feature. Here, we examined the ATM-dependent signaling and repair pathways of the DNA...
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