Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly ADP-ribose signaling is dysregulated in Huntington disease

27 Sept 2024

Abstract excerpt

) gene, translating to an expanded polyglutamine tract in the HTT protein. Age at disease onset correlates to CAG repeat length but varies by decades between individuals with identical repeat lengths. Genome-wide association studies link HD modification to DNA repair and mitochondrial health pathways. Clinical studies show elevated DNA damage in HD, even at the premanifest stage. A major DNA repair node...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium signaling and nucleotide metabolism
Share to PARP inhibition in cancer therapy

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39331414
DOI: 10.1073/pnas.2318098121

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly ADP-ribose signaling is dysregulated in Huntington diseasePMID 39331414Read ↗

Poly ADP-Ribose Signaling is Dysregulated in Huntington DiseaseSemantic proximity Read ↗

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human diseaseSemantic proximity Read ↗

Poly (ADP-ribose) in the pathogenesis of Parkinson's diseaseSemantic proximity Read ↗

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathwaysSemantic proximity Read ↗

Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Selective Inhibition of Cytosolic PARylation via PARG99: A Targeted Approach for Mitigating FUS-associated NeurodegenerationSemantic proximity Read ↗

ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes.Semantic proximity Read ↗

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.Semantic proximity Read ↗

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response.Semantic proximity Read ↗

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteinsSemantic proximity Read ↗

Novel insights into PARPs in gene expression: regulation of RNA metabolismSemantic proximity Read ↗

Poly (ADP-ribose) induces α-synuclein aggregation in neuronal-like cells and interacts with phosphorylated α-synuclein in post mortem PD samplesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.