Article

Nuclear DNA Damage is a Primary Driver of Mitochondrial Dysfunction in <i>C9ORF72</i> ALS/FTD

2026-05-21

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration associated with genomic instability and mitochondrial dysfunction, although the mechanistic relationship between these hallmarks remains unclear. To determine whether nuclear DNA damage alone induces mitochondrial dysfunction, we exploited the AID-DIvA system, selectively generating DNA double-strand breaks (DSBs) in nucl...

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Literature Corpus work: 9d3958fa-dd79-5a49-8a2d-c9ba2a34bc6d
DOI: 10.64898/2026.05.20.726184

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