Article

Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene

2026-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Somatic instability (SI) of expanded DNA repeats is a hallmark of repeat expansion disorder (REDs) and drives onset and progression in Huntington’s disease (HD) yet the absence of target engagement (TE) biomarkers for SI-modulating therapies represents a critical gap to clinical development. Here, we describe the development of the unscheduled repair synthesis assay (URSA)—combining 5-ethynyl-2’...

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Literature Corpus work: 5056027a-b378-50cf-a8be-c51a630ed9f3
DOI: 10.64898/2026.07.29.741355

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Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin geneDOI 10.64898/2026.07.29.741355Read

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