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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome

29 Mar 2024

Abstract excerpt

Abstract Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ and tau filaments from two DS brains. We found two Aβ 40 filaments (types IIIa and IIIb) that differ from those previously reported in sporadic AD and two types of Aβ 42...

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PMID: 38553642
DOI: 10.1038/s41594-024-01252-3

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